The mechanisms behind sterile inflammation induced by nanoparticles (NPs) remain unclear. NanoSIMS composite images of 12C14N− and 28Si− ion maps from THP-1 cells exposed to Silica-NPs show a prominent 28Si- signal in cells exposed to uncoated silica NPs compared to control (A) and silane-modified NPs (C). NanoSIMS revealed silica-NPs internalization in human monocytes, particularly susceptible to amorphous forms.
Recorded on a NanoSIMS 50L at Chemical Imaging Infrastructure (Chalmers University of Technology and University of Gothenburg), Sweden. Image courtesy of Per Malmberg and Elias Ranjbari.
From Gupta et al. Exploiting Mass Spectrometry to Unlock the Mechanism of Nanoparticle-Induced Inflammasome Activation. ACS nano, 17, 17, 17451–17467 (2023).