Improving the targeting of ASO therapeutic by NanoSIMS sub-cellular imaging
Friday, February 23, 2024
Cécile Becquart, post-doctoral fellow at AstraZeneca, presents recent advances in Antisense Oligonucleotides (ASOs) and the use of NanoSIMS to image and quantify the distribution and accumulation of ASOs within cells.
Key take aways include:
• Review challenges in terms of delivery of ASOs to specific tissues and inefficient escape from endolysosomal compartments which restrict their use in the clinic
• Understand the mechanisms underlying how ASOs enter cells and exit the endolysosomal space
• Learn about the specifics NanoSIMS sub-cellular quantitative imaging
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↓ Duration: 18 minutes