Vizualisation of the subcellular distribution of pharmaceutical agent - cisplatin - can yield valuable information on its targets responsible for curative potential as well as for its side effects.
Shown here platinum distribution (195Pt−) relative to biomass (12C2−, 12C14N−,31P−, 35Cl− and secondary electrons [SE]) in a mitotic SW480 human colon cancer cell upon 24 hour exposure to 250 μm of cisplatin.
Recorded on a NanoSIMS 50L at Universität Wien, Austria.
Image courtesy of Anton Legin and Arno Schintlmeister.